Visible-light photoredox synthesis of unnatural chiral α-amino acids
نویسندگان
چکیده
منابع مشابه
Visible-light photoredox synthesis of unnatural chiral α-amino acids
Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required which leads to high cost. Distinctly, it is attractive to make unnatural chiral α-...
متن کاملA modular synthesis of dithiocarbamate pendant unnatural α-amino acids.
Unnatural α-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant α-amino acids in high yields.
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A visible-light, single-electron-transfer (SET), photoredox cross-coupling for the synthesis of α-alkoxyketones has been developed. In this method, various aliphatic and aromatic acyl chlorides were successfully coupled with structurally diverse potassium alkoxymethyltrifluoroborates, producing the corresponding α-alkoxyketones with high yields. In this operationally simple and mild cross-coupl...
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2-Electron-withdrawing-group-substituted 2-bromoanilides can be converted to the corresponding 3,3-disubstituted oxindoles with high efficiency under visible light irradiation by using fac-Ir(ppy)(3) as the photoredox catalyst. This protocol is suitable for the synthesis of oxindoles with chloro and bromo atoms attached to the phenyl ring.
متن کاملPhotoredox catalysis with visible light.
The increasing need for more efficient synthetic methods and sustainable processes can be seen as a major driving force for new inventions; it also stimulates the creative rethinking of known concepts, which, in turn, will lead to the development of innovative chemistry. For example, starting from the challenge to mimic and understand enzymatic transformations, organocatalysis has now become an...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep26161